IFNG and neoplasm: Protein analysis following IFNγ treatment of parental MSRT1 cells (IFNGR1WT) compared to MSRT1 cells with IFNGR1 knockout (IFNGR1KO) showed that MEK/ERK signaling was markedly decreased in IFNGR1KO tumor cells (Fig. 6b), supporting a positive role of IFNGR1 in modulating MAPK pathway activity in response to IFNγ stimulation.