CREBBP and neoplasm: In addition, CREB-binding protein (CBP; also known as KAT3A), the paralog of p300 encoded by the CREBBP gene, was not significantly upregulated in RMC tumor cells following ICT (log2FoldChange 0.13, P-value > 0.5), suggesting that p300 is specifically engaged during RMC hyperprogression.