SETD2 and osteomyelitis: Activation of STAT1 promotes M1 polarization and enhances pro-inflammatory functions, while activation of STAT3 and STAT6 promotes M2 polarization and enhances tissue repair through IL-4, IL-13, and IL-10 signaling.94 STAT6 enhances M2 macrophage function by inhibiting NF-κB/HIF-1α-dependent transcription.95 Zhu et al.96 found that SETD2 expression is downregulated in macrophages of patients with acute pyogenic osteomyelitis, and the loss of SETD2 promotes M1 polarization and increases glycolytic activity.