MME and Sepsis: Recently, researchers have identified two new subpopulations of neutrophils, CD10-CD64+PD-L1+ and CD10-CD64+CD16low/-CD123+, which show specificity in distinguishing between sepsis and sterile inflammation.344 Utilizing single-cell and spatial omics technologies to explore the heterogeneity and functional subgroups of macrophages can guide more refined macrophage immunotherapy for the clearance of resistant bacteria.