Both EGF and Wnt can be provided by Paneth cells, which are often reduced upon intestinal injury, correlating with GVHD-related mortality.20,83,84 We conclude that the reduction in the number of growth factor-producing bystander cells after injury can—at least in part—be compensated for by combined IL-10 and IFNγ signaling. The gene discussed is IFNG; the disease is graft versus host disease.