Both EGF and Wnt can be provided by Paneth cells, which are often reduced upon intestinal injury, correlating with GVHD-related mortality.20,83,84 We conclude that the reduction in the number of growth factor-producing bystander cells after injury can—at least in part—be compensated for by combined IL-10 and IFNγ signaling. Here, EGF is linked to graft versus host disease.