IFNG and graft versus host disease: The functional relevance of IFNγ+ Treg cells is supported by a previous study demonstrating that IFNγ expression by Treg cells is essential for the prevention of murine GVHD.55 Our data demonstrate that Treg cells predominantly express IFNγ after adapting to intestinal tissue injury, suggesting the existence of mechanisms that cause intestinal Treg cells to acquire this regenerative function.