In a 2D in vitro study conducted by Yamada et al [9], TAS-115 demonstrated dose-dependent inhibition of proliferation in Yamato-SS (c-MET-dependent) and SYO-1 and HS-SY-II (PDGFRα-dependent) synovial sarcoma cell lines. The gene discussed is PDGFRA; the disease is synovial sarcoma.