Alterations in gut microbiota composition, including reduced abundance of genera such as Alistipes, may interact with this autoimmune environment, potentially modulating inflammatory markers like CRP and IL-6 differently than in individuals with low-grade metabolic inflammation [69]Dysbiosis in SLE has been associated with increased intestinal permeability, altered immune signaling, and systemic inflammation, highlighting disease-specific effects on the gut–systemic inflammation axis. This evidence concerns the gene IL6 and systemic lupus erythematosus.