Compared with COVID-19 patients without arrhythmia, those with arrhythmia were found to have significant differences in heart rate, prothrombin time (PT), activated partial thromboplastin time (APTT), blood glucose, uric acid, serum potassium, serum total cholesterol, high-sensitivity troponin I (hs-TnI), N-terminal pro B-type natriuretic peptide (NT-proBNP), aortic root diameter, left atrial diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), fractional shortening (FS), end-systolic volume (ESV), and diabetes (all P < 0.05). This evidence concerns the gene NPPB and Arrhythmia.