In summary, we found that the heart rate, PT, APTT, blood glucose, uric acid, serum potassium, serum total cholesterol, hs-TnI, NT-proBNP, aortic root diameter, LAD, LVEDD, LVEF, FS, ESV, and the presence of diabetes have significant differences in COVID-19 patients with arrhythmia compared with COVID-19 patients without arrhythmia. This evidence concerns the gene NPPB and COVID-19.