Loss-of-function mutations, including truncating mutations and copy number loss, for members of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex were identified in 8.6% (91 of 1062) of adult patients with AML (Figure 1 and Supplemental Figure 1B). Here, KITLG is linked to acute myeloid leukemia.