Moreover, ChIP enrichment analysis (ChEA) ranked ESR1 as predominant factor controlling the expression of LCOR-downregulated transcripts from the MCF-7 RNA-Seq data (Supplemental Figure 3E), suggesting that, in the HR+ BC context, LCOR functioned as a nuclear receptor corepressor governed by the activity of ERα. The gene discussed is ESR1; the disease is breast cancer.