The ACSL family consists of five isoforms—ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6—each of which has been implicated in the pathogenesis, treatment, and prognosis of diverse conditions, including metabolic disorders, cancers, cardiovascular and cerebrovascular diseases, and other clinical conditions. The gene discussed is ACSL3; the disease is cerebrovascular disorder.