ACSL3 mitigates Alzheimer’ s disease pathology by activating the brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor C (VEGF-C) signaling pathways, with its underlying mechanism potentially linked to the synthesis of ω−3 and ω−6 FAs [180]. This evidence concerns the gene BDNF and early-onset autosomal dominant Alzheimer disease.