SNCA and neurodegenerative disease: Microglia are key players in the pathophysiology and development of this individual or progressive neurodegenerative disease, which is primarily characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and the sequestration of misfolded α-synuclein into Lewy bodies (Alrouji et al. 2024a; Alshahrani et al. 2025a).