Intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) results indicated that IL-24 effectively ameliorated HFFD-induced glucose intolerance and insulin resistance, as evidenced by statistically significant differences in the area under the curve (AUC) between the treatment groups (Fig. 2E-F; quantification in Fig. S1B). The gene discussed is IL24; the disease is Insulin resistance.