AKT1 and central nervous system cancer: CBD enhances TRPV2 expression and activity,modulates Ca2+ influx, increases drug uptake, and synergizeswith cytotoxic agents to apoptosis in glioma cells without affectingnormal astrocytes. In another study,CBD upregulates acute myeloid leukemia (Aml-1) expression, crucialin GBM growth and differentiation, through a TRPV2 and PI3K/AKT-dependentmechanism.