OPN1MW and neoplasm: GZCX increasedbrain Gboxinaccumulation by 10-fold and, in GBM-bearing mice, enhanced apoptosis,reduced angiogenesis, decreased tumor burden by 3.7-fold, and prolongedsurvival. It highlighted combined CLTX–CBD-mediated BBB penetrationand GBM targeting via CLTX receptor-mediated transport