In in vitro assays,CBD exerted cytotoxic effects in glioblastoma cell lines (U87MG, T98G,CCF-STTG1), as well as in neuroblastoma (SH-SY5Y) and oligodendroglial(MO3.13) cells, with evidence of interactions among these compounds.The tumor-vs-normal differential expression of GPR55 and PINK1 furtherunderscores their value as therapeutic targets and biomarkers. The gene discussed is GPR55; the disease is glioblastoma.