CBD-,Celecoxib-, and 2,5-dimethylcelecoxib-containingliposomes exert robust anti-GBM effects by triggering apoptosis, oxidativestress, and modulating key signaling cascades. CBD + Celecoxib suppressedWnt/β-catenin and NF-κB signaling and activated the Nrf2pathway. This evidence concerns the gene NFKB1 and glioblastoma.