MGMT and glioblastoma: CBD suppressed RAD51 expressionin MGMT-methylated GBM models, suggesting a potential mechanism forits ability to enhance tumor sensitivity to TMZ. Deng et al. investigated that CBD dose-dependently reducedcell proliferation and viability across human GBM cell lines (T98G,U251, U87MG), PDGF-GBM cells from a mouse model, and cultured mouseneural progenitor cells (NPCs), exhibiting similar potency and lackingcancer-cell selectivity, through an allosteric mechanism in all testedcells.