Combining CBD with system Xc (key in antioxidant response)inhibition increased ROS, significantly reducing GSC survival, self-renewal,and invasion. Kim et al. demonstratedthat in GBM cells (U87, U373), CBD enhanced autophagy-related protein(LC3 II, Atg7, Beclin-1) and altered ferroptosis-related proteins(GPX4, SLC7A11, TFRC). The gene discussed is SLC7A11; the disease is glioblastoma.