GPR55 and central nervous system cancer: In vivo, CBD administration (0.5mg/mouse) significantly suppressed the growth of U87 glioma cellsin nude mice. Turizo Smith et al. reportthat CBD, evaluated alongside Cannabichromene, cannabigerol, and Piper nigrum derivatives, shows high-affinity bindingto glioblastoma-relevant targets GPR55 and PINK1.