BAX and central nervous system cancer: In glioma cells, ACT+ CBD liposomes increased pro-apoptotic Bax and decreased antiapoptoticBcl-xL in a dose- and time-dependent manner; the control had minimaleffect. Rybarczyk et al. reported ina study using U-138 MG and T98G cell lines that CBD-, Celecoxib-,and 2,5-dimethylcelecoxib-containing liposomes exert robust anti-GBMeffects by triggering apoptosis, oxidative stress, and modulatingkey signaling cascades.