CD8A and neoplasm: Additionally,CBD increased the expression of cluster of differentiation (CD) 103,suggesting enhanced antigen presentation, strengthened CD8 immuneresponses, and decreased the presence of innate Lymphoid Cells withinthe tumor. Wang et al. underscored thatCBD treatment notably enhanced the volume of T-cell intracellularantigen-related proteins (TIAR-1), which was closely associated withan increase in eukaryotic translation initiation factor 2 alpha (eIF2α)expression and phosphorylation of eIF2α (p-eIF2α)in tissues treated with CBD compared to the placebo group (p < 0.05).