CBDis a well-tolerated, nonpsychoactive phytocannabinoid thatexhibits antitumor activity against GBM and glioma stem-like cells.This is achieved through mechanisms such as inducing oxidative stress,activating caspases, modulating ERK and TRPV2/TRPV4 signaling, andsuppressing NF-κB and Id1. Here, NFKB1 is linked to central nervous system cancer.