TNF and central nervous system cancer: CBD/Mg-GA particles (<2μm) released ∼65% CBD at pH 7.2, reducing the viabilityof C6 glioma cells, increasing ROS, suppressing TNF-α, and modulatingNF-κB to trigger apoptosis. In an in vitro BBB model, treatmentreduced transendothelial electrical resistance (TEER) by 53.1%, suggestingpotential BBB penetration