CD8A and Epstein-Barr virus infection: We and others have observed that CD8+ T cells expand and CD4+ T cells become activated in response to EBV infection in humanized mice, that these T cells recognize autologous EBV transformed B‐cell lines, and that T‐cell depletion elevates viral loads and increases EBV associated large B‐cell lymphoma formation (Melkus et al., 2006; Shultz et al., 2010; Strowig et al., 2009; Traggiai et al., 2004).