Mesenchymal stem cell‐derived MSC‐EVs have demonstrated considerable therapeutic potential in preclinical models of ischemic stroke; MSC‐EVs also deliver pro‐regenerative factors such as VEGF, BDNF, and pro‐neurogenic miRNAs, which support angiogenesis, neurogenesis, synaptic plasticity, and axonal repair (Costa‐Ferro et al. 2024; Xiao et al. 2025; Xin et al. 2017; Zhang et al. 2017; Xue et al. 2021). Here, BDNF is linked to ischemic stroke.