At the molecular level, studies further demonstrate that hyperuricemia induces oxidative stress, endothelial dysfunction, and systemic inflammation, with hepatic LPCAT3 and CXCL‐13 upregulation driving lipid disturbances, characterized by elevated triglycerides and LDL‐C and reduced HDL‐C [29, 30]. The gene discussed is LPCAT3; the disease is hyperuricemia.