For example, acetylationof the ER chaperone GRP78 modifies its secretion in colon cancer cellsand its translocation to the membrane in cholangiocarcinoma., Given the importance of post-translational modification in influencingchaperone activity and therefore cell survival and death, it is crucialthat future studies examine the post-translational modification ofER chaperones, cancer-specificity, functional consequences and whetherthis could impact cellular localization., This evidence concerns the gene HSPA5 and cancer.