Consistent with our findings, previousstudies have demonstrated an association between ER stress pathwayactivation in glioblastoma patient tissues (n = 9)and high HSPA5 and HSP90B1 ER chaperonemRNA expression. Furthermore, a low mutationalburden (<2.5%) in the genes of interest was identified, with noclinical implications to HGG found (). The gene discussed is HSPA5; the disease is glioblastoma.