Given the lack of publiclyavailable pediatricproteome data setswhich include NNB samples, pHGG and pLGG data were retrieved fromthe “Pediatric Brain Cancer Pilot Study” for the proteinexpression comparison. A significant(p < 0.01) overexpression in pHGG samples (n = 22) compared to pLGG (n = 86) was observedfor all the ER chaperones, except CANX (Figure I–O). This evidence concerns the gene CANX and brain cancer.