The same group further developed ALN‐BSP NPs to improve their systemic circulation and tumor targeting with a bio‐responsive polymeric shell consisting of PEG, poly(lactic‐co‐glycolic acid), and MMP‐cleavable peptide.[272] Konjac glucomannan has been most widely studied for vaccine applications due to its high biocompatibility, biodegradability, and biological activity.[273, 274] Shi et al. This evidence concerns the gene IBSP and neoplasm.