CLEC7A and cancer: β‐glucan recognized by Dectin‐1 triggers a signaling cascade involving AKT, mTOR, and hypoxia‐inducible factor 1‐alpha, leading to metabolic reprogramming for trained immunity.[166] This improves the phagocytosis of cancer cells by macrophages, stimulates the recruitment and maturation of dendritic cells, and promotes T cell activation.