Mannan can also induce a pro‐inflammatory Th17 response by DCs or monocytes with the production of IL‐17, which induces shuttling of polymorphonuclear leukocytes, activation of neutrophils and macrophages, synthesis of antimicrobial peptides, and anti‐tumor responses by CD8+ T cells.[251] Mannan has a number of immunogenic activities, including tumor growth suppression via inhibition, induction of anti‐oxidative activity and autophagy in tumor cells, activation of macrophages, and targeting and repolarizing tumor‐associated macrophage (TAMs).[247]. This evidence concerns the gene CD8A and neoplasm.