The injectable alginate cryogels were further employed in combined chemoimmunotherapy using Nutlin‐3a, which elicits immunogenic cell death, specifically killing wild‐type tumor protein p53 (p53) cancer cells by activating the p53 tumor suppressor gene.[320] The alginate cryogels were loaded with GM‐CSF and CpG, and further combined with Nutlin‐3a‐loaded, spermine‐modified acetalated dextran NPs. Here, TP53 is linked to cancer.