Liquid extraction II treatment strongly downregulated VEGF and MMP‐9 mRNA expression and blocked the phosphorylation of signaling proteins relevant to angiogenesis (e.g., PI3K, AKT, p38, c‐Jun N‐terminal kinase, and p65) in human umbilical vein endothelial cells, which suggested anti‐angiogenic and anti‐metastatic properties of PLE‐II for the inhibition of tumor growth and metastasis.[377] Arabinogalactan consists of galactan and arabinose immunomodulators that can activate immune cells and influence their surface protein expression levels to suppress tumor growth and metastasis. The gene discussed is MMP9; the disease is neoplasm.