CD274 and neoplasm: Additionally, WGP led to an elevated concentration of proinflammatory cytokines such as IL‐1β, IL‐6, and IL‐8, known to increase the expression of inhibitory immune checkpoints such as PD‐L1.[309] Mao et al developed a self‐assembled nanodrug, lentinan (LNT) and ursolic acid, for the regulation of immunosuppressive TME, resulting in the inhibition of tumor progression in the CT26 CRC tumor model through mobilization of both innate and adaptive immunity.