Compared with Mtb‐infected control macrophages, the level of IL1β was significantly reduced in both HIF1‐KD and GBP1‐KD cells after infection with HN878 or CDC1551, while TNFα and IL6 were significantly reduced only in HN878‐infected HIF1‐KD and GBP1‐KD macrophages. Here, GBP1 is linked to infection.