A significant downregulation of HIF1A, NLRP3, GBP1 and ASC, and upregulation of IL1B was observed in HIF1A‐KD macrophages, while downregulation of ASC was noted in GBP1‐KD macrophages infected with HN878, compared with CDC1551 infection (Figure 4G,H). The gene discussed is IL1B; the disease is infection.