Among the other GBPs tested, expression levels of GBP4 and GBP5 were significantly upregulated in rBMDM (at 48 hpi) and THP‐1 cells (at 24 hpi) during HN878 infection, compared with CDC1551 infection, and the expression pattern of GBP3 was inconsistent between Mtb‐infected macrophages and infected rabbit lungs (Figure 4A). Here, GBP4 is linked to infection.