INS and neoplasm: PTPRN2_AS1 can adsorb miR-145-5p through the ceRNA mechanism (Huang et al., 2021), thereby relieving its inhibition on PTPRN2 and enhancing the activity of the insulin signaling pathway, promoting tumor cell glycolysis (Meng et al., 2019), which also crucial in the energy metabolism reprogramming of OSCC.