The proband (II-1), who has an implantable cardioverter-defibrillator (ICD) due to ventricular tachycardia and arrhythmias, carries a variant of uncertain significance, c.2989G>A (p.Ala997Thr) in the SCN5A gene, inherited from his mother (I-2). This evidence concerns the gene SCN5A and ventricular tachycardia.