Biochemical assessment revealed panhypopituitarism-secondary hypothyroidism [free thyroxine (FT4) <0.88 pmol/L, thyroid-stimulating hormone (TSH) 3.36 μIU/mL] and secondary adrenal insufficiency, with extremely low serum cortisol (<0.16 μg/dL) and adrenocorticotropic hormone (ACTH) 9 pg/mL. The gene discussed is POMC; the disease is Adrenal insufficiency.