TZDs: thiazolidinedione, PPARα: peroxisome proliferator-activated receptor alpha, PPARγ: peroxisome proliferator-activated receptor gamma, SPPARMα: selective peroxisome proliferator-activated receptor alpha modulators, MASLD: metabolic dysfunction-associated steatotic liver disease, T2DM: type 2 diabetes mellitus, TG: triglycerides, HDL-C: high-density lipoprotein cholesterol, ALT: alanine aminotransferase, MASH: metabolic dysfunction-associated steatohepatitis, ASBT: apical sodium-dependent bile acid transporter inhibitor, FFAs: free fatty acids. The gene discussed is PPARG; the disease is liver disorder.