We try to investigate the association between immune-inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers' predictive efficacy.<h4>Methods</h4>In this prospective cohort study of ischemic stroke patients, C-reactive protein-albumin-lymphocyte (CALLY), Systemic Immune-Inflammation Index (SII), and Systemic Inflammation Response Index (SIRI) were assessed. This evidence concerns the gene CRP and ischemic stroke.