The Venn diagram (Fig. 2B) further shows the overlap between DEGs, WGCNA-derived module genes, and lipid metabolism-associated genes, revealing seven hub genes: SERPINA1, PTGS2, ALDH2, CD36, TNF, IL1B, and GLUL. These genes are involved in lipid metabolic dysregulation and chronic inflammation, and likely play pivotal roles in CHD pathogenesis. This evidence concerns the gene GLUL and coronary artery disorder.