Experimental studies indicate that asprosin can trigger proinflammatory responses in THP-1 macrophages, increasing secretion of TNF-α, IL-1β, IL-6, IL-8, and IL-12 [29, 34], and promotes hyperlipidemia-induced endothelial inflammation via NF-κB signaling [30]. This evidence concerns the gene IL1B and hyperlipidemia.