In a rat model of AD, increased levels of p-mTOR, p-4E-BP1, p70 ribosomal S6 protein kinase 1, Interleukin 1beta (IL-1β), Interleukin 6 (IL-6), and Tumor necrosis factor-alpha (TNF-α) were observed [139]. Here, EIF4EBP1 is linked to Alzheimer disease.