In the post-mortem tissue of AD patients with amnestic mild cognitive impairment (MCI) and pre-clinical AD (PCAD), there was a significant increase in the levels of p-mTOR, p-70S6K (Thr389) and p-4E-BP1 (Thr36) in AD and MCI patients compared with controls. Here, EIF4EBP1 is linked to Alzheimer disease.