Like human beings, dogs develop similar TNFα-involved inflammatory diseases, including osteoarthritis, inflammatory bowel disease, systemic lupus erythematosus, and a variety of autoimmune skin diseases12–14, resulting in a great need for canine TNFα (cTNFα) antagonist that can be used in dogs to cure or relief such inflammatory conditions. This evidence concerns the gene TNF and systemic lupus erythematosus.