We still observed a marginally better prediction of incident delirium on the test set using APOE-ε4 and the 14 stability-selected proteins on top of demographic factors (AUC from 0.758 to 0.79, P = 0.13; PR-AUC from 0.033 to 0.036) (Extended Data Fig. 8 and Supplementary Table 10), although now with a nonsignificant AUC improvement. The gene discussed is APOE; the disease is delirium.