This may offer promising opportunities for investigating new delirium treatment targets; however, results should be interpreted with caution, as liberal P value thresholds (up to P < 0.05) were used to indicate proteomic support for our druggability assessment, and some proteins (for example, PON3 and ADAM8) were not replicated in our replication MR, although the same effect direction was still observed (Table 1 and Supplementary Data 1). The gene discussed is ADAM8; the disease is delirium.