Those biomarkers include inflammatory proteins, such as interleukin (IL)-6 and C-reactive protein (CRP)6,31,32, Alzheimer disease (AD) pathology markers6 and markers of neuronal injury, such as the neurofilament light chain (NEFL)9 and glial fibrillary acidic protein (GFAP)8. The gene discussed is NEFL; the disease is early-onset autosomal dominant Alzheimer disease.