In patients with severe AS, MVs derived from platelets (CD31+/CD61+ or CD62P+) were elevated and correlated with valvular shear stress, while elevated level of MVs from leukocytes (CD11b+) and endothelial cells (CD62E+) correlated with monocyte activation and systemic inflammation [59]. This evidence concerns the gene PECAM1 and aortic stenosis.