Furthermore, aldometanib promoted the infiltration of B cells (Supplementary information, Fig. S9n) and γδT cells (Supplementary information, Fig. S9o), both of which are known to help the recruitment and activation of CD8+ T cells in HCC.72–76 Importantly, when CD8+ T cells in mice were depleted by a neutralizing antibody, the aldometanib-enhanced enrichment of CD8+ T cells, the suppression of HCC, and the improvement of median lifespan were significantly reduced (Fig. 4m; Supplementary information, Fig. S10a–h). This evidence concerns the gene CD8A and hepatocellular carcinoma.