CD8A and hepatocellular carcinoma: It is well-established that cytotoxic lymphocytes, particularly the CD8+ T lymphocytes, act to induce the death of cancerous cells.60 To explore whether aldometanib affects the association with and infiltration of lymphocytes into the tumors, we next examined CD8+ T cells in HCC tissues from DEN-HFD mice or orthotopic allografts of Hepa1-6 cells in wild-type or AMPKα-LKO host liver.