Similarly, when cells from human HCC tissues were transplanted into the livers of NOD-SCID mice, the tumor-suppressing effects of aldometanib were observed only in mice intraperitoneally injected with human peripheral blood mononuclear cells (PBMCs) containing CD8+ T cells from healthy donors (Fig. 4n; Supplementary information, Fig. S11m–r). This evidence concerns the gene CD8A and neoplasm.