ALDOB and hepatocellular carcinoma: Consistent with previous studies showing that aldolase, particularly ALDOB, plays a role in inhibiting HCC growth46–48 and is found at lower levels in HCC patient tissues than in normal liver tissues,49,50 we observed a decrease in ALDOB in HCC cells, HCC patient tissues, and allografts (Supplementary information, Fig. S5j, k, n).