To explore what accompanies the promotion of CD8+ T cell migration, we analyzed chemokines such as CXCL9, CXCL10, and CXCL11, which are required for the infiltration of CD8+ T cells.77–79 Surprisingly, levels of these chemokines remained unchanged or even decreased after aldometanib treatment in both tumor and para-tumor tissues (Supplementary information, Figs. S13a–f, S14a–i). This evidence concerns the gene CXCL10 and neoplasm.