Aldometanib treatment changed 15 out of 28 immune cell types/subtypes examined in HCC tissues, including neutrophils, TAMs, lymphoid DCs, myeloid DCs, CD8+ TEMRA cells, CD8+ Tem, naïve CD8+ T, CD8+ Tcm, CD4+ Tregs, Th1, Th2, B, γδT, NK, and NKT cells, each of which is known to play a role in modulating the infiltration or tumoricidal effects of CD8+ Teff cells.80–83 Furthermore, some immune cell subtypes remain to be characterized, such as the various types of TAMs that can exist in 9 different subtypes in the livers of NASH mice,84 which may assist CD8+ T cells in infiltrating HCC. Here, CD4 is linked to metabolic dysfunction-associated steatohepatitis.