In stepwise-selected Cox proportional hazards models, a 10-year increase in age (HR [95% CI], 3.46 [2.66,4.51]; P < 0.001), current smoking (HR [95% CI], 2.17 [1.08,4.39]; P = 0.030), a 10 mg/dL increase in low-density lipoprotein (HR [95% CI], 1.17 [1.09,1.27]; P < 0.001), interleukin-6 (HR [95% CI], 1.62 [1.25, 2.09]; P < 0.001), and urinary isoprostanes (HR [95% CI], 1.39 [1.03, 1.88]; P = 0.033) were associated with higher MACE, while female sex (HR [95% CI], 0.58 [0.37,0.95]; P = 0.028) was associated with lower MACE among adults with preclinical hypertension. The gene discussed is IL6; the disease is Hypertension.