Similarly, genes which increased in hypoxia, but decreased in stable hypoxia in wild-type cells but not in TP53 silenced cells included HPSE encoding heparinase, which is elevated in serum of breast cancer patients and has poor prognosis46, as well as NUDT9 which modulates HIF-1 activity (Fig. 6E)47. This evidence concerns the gene TP53 and breast cancer.