HACD3 and cancer: O < H < N pattern genes which were found to be TP53 dependent were mostly related to lipid metabolism, including FKBP7 a fatty acid binding protein, and HACD3 encoding for 3-hydroxyacyl-CoA dehydratase 3, as well as other pro-invasive genes THAP6 and LRRCC1, both associated with increased metastasis in various cancers (Fig. 6C).