MCAM and endothelial dysfunction: The inflammatory process was associated with increased endothelial dysfunction marker CD146 and Vascular cell adhesion marker 1(VCAM1) mRNA levels and CD146 protein expression, compared to sham mice, and this effect was significantly more pronounced in WTGal−3−/−BM mice, 48 h and 28d after rIR (Fig. 4B–D).