Macrophage analysis showed an increased presence of M2 macrophages (CD163-positive) in APC; KRAS mut tumors (APC mut vs. APC; KRAS mut : 56.9 ± 11.7 vs. 95.5 ± 11.2, P = 0.01); however, the M1/M2 ratio did not differ significantly between the two genotypes (3.6 ± 0.92 vs. 1.4 ± 0.91,P = 0.09), indicating that both inflammatory and immunosuppressive macrophage populations coexisted within the tumor microenvironment (Fig. 8a). This evidence concerns the gene KRAS and neoplasm.