ESR1 and Familial prostate cancer: The role played by ER-α in prostate cancer70, alongside the high comorbidity seen between prostate cancer and ED71, raised the concern that the effect seen in ESR1 is driven by prostate cancer and not directly by EHR-ED; however, previous GWAS publications indicate that the effect of ESR1 on prostate cancer is low72 or null22,32.