In all analyses, the strongest effect variants mapped to a non-coding region known to regulate SIM1, previously associated with erectile dysfunction: rs78677597 (Europeans) (p = 5.32 × 10−139), and rs17185536 (Africans (p = 1.17 × 10−9) and cross-ancestry (p = 5.3 × 10−138)). Here, SIM1 is linked to erectile dysfunction.