CASC19 and Familial prostate cancer: Several studies associate this gene, and specifically CASC19*rs138042437 (lead SNP for this locus in our study), with prostate cancer58–61, a trait we found to have a bidirectional causal relationship with EHR-ED, in accordance with known strong comorbidity between the two traits62,63 and with increased prevalence of prostate cancer among ED subjects in our sample as well.