Participants with type 1 diabetes had lower glucose infusion rate (GIR) during the high-dose phase (61.9 ± 20.1 μmol/kgFFM/min and 87.7 ± 18.4 μmol/kgFFM/min respectively; p = 0.00001), indicating impaired insulin-stimulated glucose uptake by skeletal muscle (Fig. 1). Here, INS is linked to type 1 diabetes mellitus.