MARS1 and Sepsis: Most importantly, although many sepsis subtypes have been published at present, due to the different goals, the use of different clinical indicators, different machine learning models, or black-box algorithms, there are varying degrees of differences among these subtypes, ultimately resulting in low comparability or overlap among them (like MARS1-4, SRS1-2, Hyper or hypo inflammatory, and SENECA subtypes)8, and no shared classification tools or platforms have been simultaneously proposed.