CREB3L2 and neoplasm: Next, we examined CREB3L2 expression in HCC tissues at the protein level, 10 pairs of tissues were randomly selected from Cohort 1 for Western blotting, among the 9 pairs of samples, the expression level of CREB3L2 was higher in tumor tissues, with only one pair showing relatively lower expression in the tumor (Fig. 1E).