Therefore,preliminary analysis of the correlation between CREB3L2 and the expression of key molecules of lipid metabolism in HCC tissues by RNA-seq data from HCC in TCGA (Fig. 4G).In addition, Pearson correlation analysis showed a significant correlation between the expression level of CREB3L2 and the fatty acid synthases ACLY, ACC1, FASN and SCD (Fig. 4H). The gene discussed is ACLY; the disease is hepatocellular carcinoma.