Then, we evaluated the impact of CREB3L2 on SREBP1 expression in HCC cells, and neither the knockdown nor the overexpression of CREB3L2 exerted an influence on the SREBP1 mRNA level, but it did affect SREBP1 expression at the protein level (Fig. 5D and Supplementary Fig. S4A), suggesting that CREB3L2 may regulate the post-translational modification of SREBP1. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.