Conversely, an elevation in the expression level of CREB3L2 was accompanied by a concomitant increase in both the tumor growth rate and tumor dimensions (Fig. 3B), with corresponding changes in the number of lung metastatic nodules in mice based on the knockdown or overexpression of CREB3L2 (Fig. 3C, D). This evidence concerns the gene CREB3L2 and neoplasm.