In contrast, the TIMM23-KO + TIMM23-PARGP1-FLAG/TIMM23-KO + TIMM23-PARGP1-FLAG + Dox groups exhibited significantly increased tumor volume and weight compared to the TIMM23-KO + oe-NC/TIMM23-KO + oe-NC + Dox groups. The gene discussed is TIMM23; the disease is neoplasm.