Compared to the TIMM23-KO + oe-NC + Dox group, the TIMM23-KO + TIMM23-PARGP1-FLAG + Dox group showed no significant change in TIMM23 expression but a significant increase in TIMM23-PARGP1 expression in tumor tissues (Fig. 8A, Fig. S12B). This evidence concerns the gene PARGP1 and neoplasm.