It is important to note that this OT-I experiment was performed to define transcriptomic differences between IL-18Rαhi and IL-18Rαlo CD8 T cells subsets following high dose influenza virus infection (the highest approved dose by our ethics) rather than during severe disease, as transferring large numbers of transgenic OT-I cells into mice prevents significant body weight loss following viral infection. Here, CD8A is linked to viral infectious disease.