To define differences between antigen-specific CD8 T cells with high IL-18Rα and low IL-18Rα levels during high dose IAV infection, we performed RNA sequencing using a well-established OVA/OT-I system31 and infection with a recombinant X31 influenza virus strain expressing the OVA antigen (HKx31-OVA)32. This evidence concerns the gene IL18R1 and infection.