PPARA and colorectal carcinoma: Despite the intriguing findings, this study has several limitations: (1) The underlying cause of hnRNP A1 upregulation in CRC remains unclear, and further exploration of its mechanisms could offer new opportunities for developing CRC therapeutic strategies; (2) The specific regulatory pathway between hnRNP A1 and PPARα needs further investigation; (3) In vivo experiments tested only the functionality of hnRNP A1 knockdown cells, without additional validation of PPARα.