To investigate whether hnRNP A1 silencing induces lipid accumulation by stabilizing PPARα mRNA and regulating de novo fatty acid (FA) synthesis, we measured the mRNA expression of key FA synthesizing enzymes, including FASN, ACC1, ACLY, and SCD1, in CRC cells with varying levels of hnRNP A1 expression. This evidence concerns the gene PPARA and colorectal carcinoma.