PPARA and colorectal carcinoma: Despite some interesting findings, this study has several limitations: (1) The cause of hnRNP A1 upregulation in CRC remains unclear, and its underlying mechanism may provide more opportunities for developing CRC therapeutic drugs; (2) The specific regulatory pathways between hnRNP A1 and PPARα need further investigation; (3) In vivo experiments tested only the function of hnRNP A1 knockdown cells, without further validation of PPARα.