The infiltration of both CD68-labeled macrophages, which are the most predominant immune cells in the pancreatic cancer microenvironment [35, 36], and CD11C-labeled DC, which are essential for tumor cell antigen presentation [37], was significantly suppressed in the group with local invasion, IGF2BP3, or high EMP1 expression (Fig. 7B–D). This evidence concerns the gene IGF2BP3 and familial pancreatic carcinoma.