In pancreatic cancer cytoskeleton staining (Fig. 5B), scratch assay (Fig. 5C), and Transwell migration and invasion (Fig. 5D) assays, we found that the migratory and invasive abilities of pancreatic cancer cells, enhanced by IGF2BP3 overexpression, were significantly reduced by EMP1 depletion. Here, IGF2BP3 is linked to familial pancreatic carcinoma.