Furthermore, we analyzed the effects on EMP1 mRNA stability after METTL3 knockdown or overexpression and showed that overexpression of METTL3 in pancreatic cancer cells increased the stability of EMP1 mRNA, and consistently, the stability of EMP1 mRNA was inhibited after METTL3 knockdown (Fig. 3L, M). This evidence concerns the gene METTL3 and familial pancreatic carcinoma.