Besides, Co-IP analysis illustrated that in pancreatic cancer cells, SMAD7 could bind to the VASP protein (Fig. 6I), and after knockdown of EMP1 protein in pancreatic cancer cells, the ability of VASP protein binding to SMAD7 was inhibited, and the reverse result was obtained by overexpression of EMP1 (Fig. 6J). Here, EMP1 is linked to familial pancreatic carcinoma.