To induce reduced expression of Fkbpl that was previously observed in women early in pregnancy who proceeded to develop preeclampsia [1], we employed various transfection approaches to deliver a CRISPR/Cas9 pDNA into trophoblast cells, resulting in the establishment of a number of genetically-edited Fkbpl-K/O cell lines, albeit full Fkbpl knockout was not viable. This evidence concerns the gene FKBPL and preeclampsia.