MSC-sEVs increased proliferation in WT ACH-3P cells at 1 μg (p < 0.05) and 2 μg (p < 0.01) doses, however, were not effective in either 17% or 38% Fkbpl-K/O clones, suggesting that FKBPL is an important mechanism of MSC-sEV-mediated therapeutic effect in trophoblasts in the context of preeclampsia. Here, FKBPL is linked to preeclampsia.