IDO1 and autoimmune uveitis: In autoimmune uveitis, the elevated lactate levels in microglia can lead to the Kla modification of Yin Yang 1 (YY1), thereby promoting the transcriptional activation of genes such as signal transducer and activator of transcription 3 (STAT3), chemokine (C-C motif) ligand 5 (CCL5), indoleamine 2,3-dioxygenase 1 (IDO1), and semaphorin 4 A (SEMA4A), which in turn promotes the development of inflammation [67].