In colorectal cancer (CRC), the Kla modification of histone deacetylase 1 (HDAC1) reduces the levels of RNA demethylases fat mass and obesity-associated protein (FTO) and ALKBH5, increasing m6A modification on the mRNA of FSP1 to upregulate ferroptosis inhibitor protein ferroptosis suppressor 1 (FSP1), inhibiting ferroptosis and promoting tumor growth [161]. The gene discussed is AIFM2; the disease is neoplasm.