ZFP36L1 and neoplasm: In vivo studies using ZFP36L1 knockdown (shZFP36L1) or overexpression (oeZFP36L1) 143B cell lines injected into nude mice showed that ZFP36L1 downregulation significantly enhanced tumor survival from MTX treatment (Fig. 1F–H, Supplementary Fig. 1D, E).