We identified that an increased number of SYN+TIM-3+ tumour cells was associated with a longer OS (HRlow vs high 3.57 [95% CI 1.104–11.561], p = 0.0336, Wald test) (Supplementary Fig. S3A), and PFS (HRlow vs high 2.24 [95% CI 1.242–4.034], p = 0.0073, Wald test) (Supplementary Fig. S3B). This evidence concerns the gene HAVCR2 and neoplasm.