In contrast, the CC genotype of FCN2 rs7865453 was significantly less frequent among SLE patients (16.0%) compared with HCs (27.0%) (OR, 0.51 [95% CI, 0.32 to 0.84]; P = 0.007), and a lesser frequency of the minor C allele was noted among SLE patients (23.2%) compared with HCs (33.0%) (OR, 0.62 [95% CI, 0.45 to 0.84]; P = 0.002). The gene discussed is FCN2; the disease is systemic lupus erythematosus.