The high occurrence of the AA genotype and the minor A allele of FCN1 rs2989727, as well as the AA genotype and the major A allele of FCN1 rs1071583, among LN patients suggests that FCN1 variants may be associated with renal involvement in SLE and therefore could serve as a potential marker for predicting renal complications in SLE. This evidence concerns the gene FCN1 and systemic lupus erythematosus.