Moreover, a recent study showed that TRAF1’s ability to negatively regulate the linear ubiquitination of ASC is crucial for controlling inflammasome activation and that TRAF1-deficient mice exhibited exacerbated inflammation and joint swelling in the MSU crystal–induced arthritis model, an NLRP3 inflammasome–dependent model of gout, compared to WT littermates.4 The gene discussed is NLRP3; the disease is arthritic joint disease.