RAPGEF5 and cancer: More specifically, within the PI3K/Akt/mTOR pathway, the following pathways and proteins were downregulated in cancer: GFR/EGFR (EGFR_pY1173), BAD/BCL2L8 (BCL2A1), 4E-BP1 (4E-BP1_pS65), IGF1R (IGF1R_pY1135_Y1136), Rictor (Rictor_pT1135 and Rictor), whereas mTOR was upregulated in the cancer cohort.