After these cells were infected with Bac16 or STOP45 viruses for 24 h, the primary infection of Bac16 viruses greatly induced Filamin A phosphorylation while STOP45 viral infection weakly increased it in WT cells, and no Filamin A phosphorylation was observed in either Filamin A KO or KI cells (Fig 5B). This evidence concerns the gene FLNA and viral infectious disease.