FLNA and viral infectious disease: In conclusion, ORF45 induces Filamin A phosphorylation during KSHV primary infection and lytic replication, and then ORF45-Filamin A axis promotes cell detachment and migration and de novo and cell-contact dependent viral infection, to mediate the effective cell movement and viral transmission during lytic cycle, providing the importance for KSHV persistent infection and tumorigenesis.